| Publication Type: | Journal Article |
| Year of Publication: | 2007 |
| Authors: | P. Rajska, Knezl, V., Kazimirova, M., Takac, P., Roller, L., Vidlicka, L., Ciampor, F., Labuda, M., Weston-Davies, W., Nuttall, P. A. |
| Journal: | Medical and Veterinary Entomology |
| Volume: | 21 |
| Pagination: | 384-389 |
| Date Published: | December |
| Type of Article: | Article |
| ISBN Number: | 0269-283X |
| Keywords: | Cephalic glands, Digestive system, evidence for vasoactivity]., glands / Salivary gland extracts / Effects on isolated perfused, Hybomitra bimaculata, Hybomitra bimaculata (Tabanidae)., mammalian heart, Tabanus bromius, Tabanus bromius (Tabanidae)., Tabanus glaucopis (Tabanidae)., Tabanus glaucopis [Salivary |
| Abstract: | The speed with which horseflies (Diptera: Tabanidae) obtain a bloodmeal suggests they have potent vasodilators. We used isolated perfused rat heart to examine the vasoactivity of salivary gland extracts (SGEs) of three horsefly species, Hybomitra bimaculata Macquart, Tabanus bromius Linnaeus and Tabanus glaucopis Meigen. Administration of horsefly SGEs to the heart produced biphasic coronary responses: a decrease and subsequent increase in coronary flow (CF), characterized by initial vasoconstriction followed by prolonged vasodilation of coronary vessels. However, although SGEs of H. bimaculata induced a significant decrease in left ventricular pressure (LVP), the effect on changes in CF was not significant except at the highest dose tested. The ability to reduce LVP without significantly lowering CF, or affecting heart rate and rhythm, represents a unique set of properties that have considerable therapeutic potential if they can be reproduced by a single molecule. |
| URL: | <Go to ISI>://ZOOREC:ZOOR14407041275 |